MSDS for 1,3-Dibromopropane

Identification

Product Name: 1,3-Dibromopropane
Chemical Formula: C3H6Br2
Synonyms: Trimethylene dibromide, Propane, 1,3-dibromo-
CAS Number: 109-64-8
Recommended Use: Laboratory chemical, intermediate for organic synthesis
Manufacturer Contact Details: Available from supplier
Emergency Contact Number: Use country-specific poison control or manufacturer’s emergency line

Hazard Identification

Hazard Classification: Acute toxicity (oral, inhalation, dermal), Skin and eye irritation, Specific target organ toxicity
Pictograms: Skull and crossbones, exclamation mark
Signal Word: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled. Causes skin irritation, serious eye irritation. Suspected of causing cancer. Toxic to aquatic life with long lasting effects.
Precautionary Statements: Avoid breathing vapors. Wear protective gloves, clothing, and eye protection. Wash thoroughly after handling. Do not release to the environment.
Other Hazards: High vapor concentrations can cause central nervous system depression, dizziness, or unconsciousness.

Composition / Information on Ingredients

Chemical Name: 1,3-Dibromopropane
CAS Number: 109-64-8
Concentration: 99% or higher
Impurities: Trace brominated alkanes; specific impurity levels available from supplier
Exposure Limits: None established by OSHA; response based on general toxicology of brominated hydrocarbons

First Aid Measures

Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, keep flushing eyes, seek immediate medical attention.
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water and mild soap. Get medical help if irritation develops.
Inhalation: Move exposed person to fresh air, ensure airways are open. If breathing stops, provide artificial respiration. Call a physician promptly.
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical personnel. Seek immediate medical care.
Most Important Symptoms and Effects: Causes eye and skin irritation; possible headaches, dizziness, lung effects, and symptoms of central nervous system involvement.
Notes for Physicians: Treat symptomatically and supportively. No specific antidote.

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide. Water spray can cool containers.
Unsuitable Extinguishing Media: Avoid water jets which may spread the chemical.
Specific Hazards: Releases hazardous or toxic gases including hydrogen bromide and carbon oxides when burned.
Special Protective Equipment: Firefighters should wear full protective gear with self-contained breathing apparatus.
Fire-fighting Instructions: Control runoff to prevent entry into water systems. Use remote spray if containers heated by fire.
Explosion Data: Not expected to be explosive, but vapors can form flammable mixtures with air at elevated temperatures.

Accidental Release Measures

Personal Precautions: Isolate spill area, ventilate space. Use appropriate personal protection—gloves, goggles, chemical-resistant suit.
Environmental Precautions: Prevent entry into waterways, soil, or drains. Notify authorities if significant contamination occurs.
Small Spill Cleanup: Absorb with inert material (sand, earth, vermiculite), place in chemical waste container, seal, label for disposal.
Large Spill Cleanup: Evacuate area, dike spillage, collect with vacuum or pump equipped with chemical filters. Decontaminate area with soap and water after removal.
Decontamination: Dispose residues as hazardous waste as per regulatory guidelines.

Handling and Storage

Handling: Only handle with adequate ventilation. Avoid inhalation of vapors, direct contact with eyes, skin, and clothing. Do not eat, drink, or smoke during use. Use only non-sparking tools.
Storage Conditions: Keep container tightly closed and stored in a cool, dry, well-ventilated area away from sources of ignition, oxidizers, and incompatible materials.
Storage Class: Store in corrosives cabinet, away from bases and oxidizers. Label all containers clearly.
Transfer Precautions: Ground and bond containers to prevent static discharge during transfer.
Incompatibles: Strong bases, strong oxidizing agents, reducing agents, and alkali metals.

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation to keep airborne concentrations below recommended limits. Eyewash stations and safety showers should be readily accessible.
Respiratory Protection: Use NIOSH-approved respirator if vapors exceed recommended exposure limits or in poorly ventilated environments.
Skin Protection: Wear impermeable gloves (nitrile, butyl rubber), lab coat or coveralls.
Eye and Face Protection: Wear safety goggles with side shields or full face shield.
Hygiene Measures: Wash hands thoroughly after handling. Remove contaminated clothing and wash before reuse.
Environmental Controls: Prevent discharge into the environment and follow site-specific procedures for waste containment.

Physical and Chemical Properties

Physical State: Clear to pale yellow liquid
Odor: Sweet, chloroform-like
Odor Threshold: Data not available
pH: Not applicable
Melting Point: -57°C
Boiling Point: 196-198°C
Flash Point: 85°C (185°F; closed cup)
Evaporation Rate: Slower than ether
Flammability: Not classified as highly flammable but may support combustion at elevated temperatures
Vapor Pressure: 0.1 mmHg at 20°C
Vapor Density: 6.6 (air = 1)
Relative Density: 2.17 (water = 1)
Solubility: Slightly soluble in water, miscible with many organic solvents
Partition Coefficient: log Kow = 2.09
Auto-ignition Temperature: 543°C
Decomposition Temperature: Data not available
Viscosity: Slightly viscous liquid
Molecular Mass: 201.89 g/mol

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions and normal use.
Possibility of Hazardous Reactions: May react violently with strong alkalies and oxidizing agents; forms toxic gases upon decomposition.
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide, bromine.
Conditions to Avoid: Excessive heat, sparks, open flames, high humidity, direct sunlight.
Incompatible Materials: Strong bases, strong oxidizers, reducing agents, and alkali metals.
Polymerization: No hazardous polymerization expected.

Toxicological Information

Acute Toxicity (Oral): LD50 (rat): 980 mg/kg
Acute Toxicity (Dermal): Data not well documented; expected moderate toxicity based on structure.
Acute Toxicity (Inhalation): LC50 (rat, 4h): 10 mg/L (estimation)
Skin Corrosion/Irritation: Causes moderate to severe irritation, especially with prolonged exposure.
Eye Damage/Irritation: High risk of conjunctival irritation, redness, pain.
Respiratory Sensitization: May cause respiratory tract irritation, headache, drowsiness, and dizziness.
Mutagenicity: Evidence from animal studies suggests possible genotoxicity.
Carcinogenicity: Not listed by IARC, NTP, or OSHA but structurally similar compounds are suspect carcinogens. Use caution.
Reproductive Toxicity: No reproductive studies found; precautionary approach recommended.
Specific Target Organ Toxicity: Repeated exposure affects central nervous system and liver.
Other Information: Handling without adequate protection can cause sensitization. Long-term animal studies limited.

Ecological Information

Ecotoxicity: Highly toxic to aquatic life, especially fish and invertebrates.
Persistence and Degradability: Not readily biodegradable. Tends to persist in the environment for extended periods.
Bioaccumulative Potential: Moderate potential for bioaccumulation due to physicochemical properties.
Mobility in Soil: Moderately mobile in soil; potential for groundwater contamination.
PBT/vPvB Results: Not classified as persistent, bioaccumulative, and toxic or very persistent/very bioaccumulative under current standards, but precaution is advised.
Other Adverse Effects: Brominated organics can disrupt sensitive aquatic food webs. Spill prevention critical.

Disposal Considerations

Waste Disposal: Treat as hazardous waste under local and national regulations. Use authorized hazardous waste disposal contractor.
Disposal Containers: Place waste in tightly sealed, properly labeled containers.
Incineration: Preferred disposal method through licensed chemical incinerator where permitted.
Contaminated Packaging: Wash with water where possible before disposal. Otherwise, treat packaging the same way as chemical waste.
Precautions: Avoid release to environment. Never pour into drains or sewers.
Regulatory Reference: RCRA (Resource Conservation and Recovery Act) U.S. regulations, local hazardous waste guidelines.

Transport Information

UN Number: 2688
UN Proper Shipping Name: 1,3-Dibromopropane
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Labels Required: Toxic
Marine Pollutant: Yes
Special Precautions: Avoid temperature extremes; handle containers gently to avoid rupture.
Environmental Hazards: Yes, hazardous to aquatic environment. Avoid spillage at ports and near water bodies.
Transport Note: Comply with DOT, ADR, IMDG, and IATA regulations.
Additional Info: Emergency response guidebook (ERG) code: 151

Regulatory Information

OSHA Status: Hazardous chemical under OSHA Hazard Communication Standard.
TSCA Inventory: Listed in the U.S. Toxic Substances Control Act (TSCA) inventory.
SARA Title III: Subject to reporting under the Emergency Planning and Community Right-to-Know Act (EPCRA) for certain quantities.
CERCLA Reportable Quantity: No specific RQ for this substance; treat as hazardous if a large accidental release occurs.
California Proposition 65: Not listed, but caution advised for workplace exposures.
EU: Classified as hazardous according to CLP Regulation (EC) No 1272/2008.
Other Regulations: Check country-specific chemical control legislations. SDS available on request from suppliers. Recommended to review any specific workplace air or drinking water standards where required.